Publications

Independent Research 

39.  Modular synthesis of α,α-diaryl α-amino esters via Bi(V)-mediated arylation/SN2-displacement of Kukhtin–Ramirez intermediates

​Calcatelli, A.; Denton, R. M.; Ball, L. T. Org. Lett. 2022, 24, 8002.

38. In Situ Silane Activation Enables Catalytic Reduction of Carboxylic Acids (with GSK)

Stoll. E.L., Barber, T.; Hirst, D.J.; Denton, R.M. Chem. Commun. 2022, 58, 3509.

37. A Practical Catalytic Reductive Amination of Carboxylic Acids (with GSK)

Stoll, E.L.; Tongue, T.; Andrews, K.G.; Hirst, D.G.; Valette, D.; Denton, R.M., Chem. Sci., 2020, 11, 9494.

36. Synthesis of 18O-labelled alcohols from unlabelled alcohols (with GSK)

Beddoe, R.H.; Edwards, D.C.; Goodman, L.; Sneddon, H.F.; Denton, R.M. Chem. Commun., 2020, 56, 6480. Front cover.

35. Development of a more sustainable Appel reaction (with GSK)

Jordan, A.*; Sneddon, H.F.; Denton, R.M. ACS Sustainable Chem. Eng. 2020, 8, 5, 2300–2309

34. Redox Neutral Organocatalytic Mitsunobu Reactions (with GSK)

Beddoe, R.H.; Andrews, K.G.; Magne, V.; Cuthbertson, J.D.; Saska, J.; Shannon-Little, A.L.; Shanahan, S.E.; Sneddon, H.F.; Denton, R.M.  Science, 2019, 365, 910

33. The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the art (with GSK)

Beddoe, R.H.; Sneddon, H.F.; Denton, R.M. Org. Biomol. Chem. 2018, 16, 7774

32. A More Critical Role for Silicon in the Catalytic Staudinger Amidation: Silanes as Non-Innocent Reductants

Andrews, K.; Denton, R.M. Chem. Commun. 2017, 53, 7971. Front cover.

31. A Practical and Catalyst-Free Trifluoroethylation Reaction of Amines Using Trifluoroacetic Acid.

Andrews, K.; Faizova, R.; Denton, R.M. Nature Commun. 2017, 8, 15913.

30. Synthesis of Malhamensilipin A Exploiting Iterative Epoxidation/Chlorination: Experimental and Computational Analysis of Epoxide-Derived Chloronium Ions

Saska, J.; Lewis, W.; Paton, R.; Denton R.M. Chem. Sci. 2016, 7, 7040.

29. Synthesis of Quaternary Aryl Phosphonium Salts: Photoredox Initiated Phosphine Arylation

Fearnley, A.F.; An, J.; Jackson, M.; Lindovska, P.; Denton, R.M. Chem. Commun. 2016, 52, 4987.

28. Catalytic Reductive N-Alkylation of Amines using Carboxylic Acids

Andrews, K.; Summers, D.; Donnelly, L.; Denton, R.M. Chem. Commun. 2016, 52, 1855.

27. Development of a Redox-Free Mitsunobu Reaction Exploiting Phosphine Oxides as Precursors to Dioxyphosphoranes (with GSK)

Tang, X.; Chapman, C.; Whiting M.; Denton, R.M. Chem. Commun. 2014, 50, 7340.

26. The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions

Jie, A.; Denton, R.M.; Lambert T.L.; Nacsa, E. Org. Biomol. Chem. 2014, 12, 2993.

25. A Simple Method for Appel Reactions Using a Polystyrene Supported Phopshine Oxide

Tang, X.; An, J.; Denton, R.M. Tetrahedron Lett. 2014, 4, 799. 

24. Heteroatom Methods (review article)

An, J.; Denton, R.M. Annu. Rep. Org. Chem., Sect. B: Org. Chem. 2013, 109, 167.

23. Phosphorus(V)-Catalysed Dichlorination Reactions of Aldehydes

An, J.;  Tang, X.; Moore, J.; Lewis, W.;  Denton, R.M. Tetrahedron 2013, 69, 8769.

22. A Strategy For The Synthesis Of The Fargenone/Fargenin Family of Natural Products: Synthesis Of The Tricyclic Core

R.M. Denton, J.S. Scragg, Org. Biomol. Chem 2012, 10, 5629

21. Phosphonium Salt-Catalysed Synthesis of Nitriles From In Situ Activated Oximes

Denton R.M.; An, J.; Lindovska, P.; Lewis, W. Tetrahedron, 2012, 68, 2899

20. Catalytic Phosphorus(V)-Mediated Nucleophilic Substitution Reactions: Development Of A Catalytic Appel Reaction

Denton, R.M.; An, J.; Adeniran, B.; Blake, A.; Lewis, W.; Poulton, A. J. Org. Chem. 2011, 76, 6749

Highlighted in ACS New and Noteworthy Chemistry. Highlighted in Functional Group Transformations on the Organic Chemistry Portal. Highlighted in Green Chemistry Articles of Interest to the Pharmaceutical Industry in Organic Process Research and Development. Highlighted in Sustainable Chemistry Challenges and Practices for the Chemical and Pharmacuetical Industry.

19. A Concise Synthesis of O-methyl Honokiol

Denton, R.M.; Scragg, J.T.; Saska, J. Tetrahedron Lett. 2011, 52, 2554

18. Catalysis of Phosphorus(V)-Mediated Transformations: Catalytic Dichlorination of Epoxides Under Appel Conditions

Denton, R.M.; Tang, X.; Przeslak, A. Org. Lett. 2010, 12, 4678

17. Phosphine Oxide-Catalysed Chlorination of Alcohols Under Appel Conditions

Denton, R.M.; An, J. ; Adeniran, B. Chem. Commun. 2010, 46, 3025

16. A Concise Synthesis Of Honokiol

Denton, R.M.; Scragg, J.T.; Galofre, A.M.; Gui, X.; Lewis, W. Tetrahedron 2010, 66, 8029

15. A Concise Synthesis Of Dunnianol

Denton, R.M.; Scragg, J.T. Synlett 2010, 633

Postdoctoral Research

14. Lesser-Known Enabling Technologies For Organic Synthesis

O’Brien, M.; Denton, R.M.; Ley, S.V. Synthesis 2010, 8, 1157

13. RAR Signalling Regulates Choroid Fissure Closure Through Independent Mechanisms In The Ventral Optic Cup and Periocular Mesenchym

Lupo, G.; Gestri, G.;  O’Brien, M.;  Denton, R.M. Chandraratna, R.A.S.; Ley, S.V.; Harris W.A.; Wilson, S.W. Proc. Nat. Acad. Sci. 2011, 108, 8698.

12. Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

Nicolaou, K.C.; Frederick, M.O.; Burtuloso, A.; Denton, R.M.; Rivas, F.; Cole, K.P. R.; Aversa, R. Gibe, R.; Umezawa, T.; Suzuki, T. J. Am. Chem. Soc. 2008, 130, 7466–7476

11. Total Synthesis of Artochamins F, H, I and J Through Cascade Reactions

Nicolaou, K.C.; Lister, T.; Denton, R.M.; Gelin, C.F. Tetrahedron 2008, 64, 4736

10. Design, Synthesis and Biological Evaluation of Platensimycin Analogs with Varying Degrees of Molecular Complexity

Nicolaou, K.C.; Stepan, A.F.; Lister, T.; Li, A.; Montero, A.; Tria, G.S.; Turner, C.I.; Tang, Y.; Wang, J.; Denton, R.M.; Edmonds, D.J. J. Am. Chem. Soc. 2008, 130, 13110

9. The Synthesis of Azadirachtin: A Potent Insect Antifeedant

Ley, S.V.; Somovilla, A.A.; Anderson, J.C.; Ayats, C.; Bänteli, R.; Beckmann, R.E.; Boyer, A.; M. Brasca, M.G.; Brice, A.; Broughton, H.B.; Burke, B.J.; Cleator, E.; Craig, D.; Denholm, A.A.; Denton, R.M.; Reville, T.D.; Gobbi,  L.B.; Göbel, M.; Gray, B.L.; Grossmann, R.B.; Gutteridge, C.E.; Hahn, N.; Harding, S.L.; Jennens, D.C.; Jennens, L.; Lovell, P.J.; Lovell, H.J.; de la Puente, M.L.; Kolb, H.C.; Koot, W.J.; Maslen, S.L.; McCusker, C.F.; Mattes, A.; Pape, A.R.; Pinto, A.; Santafianos, D.; Scott, J.S.; Smith, S.C.; Somers, A.Q.; Spilling, C.D.; Stelzer, F.; Toogood, P.L.; Turner, R.M.; Veitch, G.E.; Wood, A.; Zumbrunn, C. Chem. Eur. J. 200814, 10683-10704

8. Metathesis Reactions in the Synthesis of Complex Molecules

Nicolaou K.C.; Ortiz, A.; Denton, R.M. Chemica Oggi, 2007, 5, 70–72, 74–76

7. Cascade Reactions Involving Formal [2+2] Cycloadditions: Total Synthesis of Artochamins F,H,I,J

Nicolaou, K.C.; Lister, T.; Denton, R.M.; Gelin, C.F. Angew. Chem. Int. Ed. 2007, 39, 7501

6. Chemical Synthesis of the GHIJK Ring System and Experimental Support for the Originally Assigned Structure of Maitotoxin

Nicolaou, K.C.; Cole, K.P.; Frederick, M.O.; Aversa, R.J.; Denton, R.M. Angew. Chem. Int. Ed. 2007, 46, 8875–8879

5. Adamantaplatensimycin a Bioactive Analogue of Platensimycin

Nicolaou, K.C.; Lister, T.; Denton, R.M; Montero, A.; Edmonds, D.J Angew. Chem. Int. Ed. 2007, 46, 4712

4. Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B

Nicolaou, K.C.; Denton, R.M.; Lenzen, A.; Edmonds, D.J.; Li, A.; Milburn, R.; Harrison, S. Angew. Chem. Int. Ed. 2006, 118, 2130

Doctoral Research

3. Asymmetric Synthesis of 6’-hydroxyarenarol: The Proposed Biosynthetic Precursor to Popolohuanone E

Munday, R.H.; Denton, R.M.; Anderson, J.C. J. Org. Chem. 2008, 73, 8033

2. A Biomimetic Strategy for the Synthesis of the Tricyclic Aromatic Core of Popolohuanone E

Anderson, J.C.; Denton, R.M.; Wilson, C. Org. Lett. 2005,7, 123

1. Synthesis of Dibenzofuran-1,4-Diones Using the Dotz Benzannulation

Anderson, J.C., Denton, R.M.; Hicken, G.; Wilson, C. Tetrahedron 2004, 60, 2327

Book Chapters and Conference Abstracts

2. Modern NMR Spectroscopy

in Organic Chemist’s Desk Reference Denton, R.M., Ed. C. Cooper. 2010, CRC Press

1. Total Synthesis of Artochamins F,H,I and J

K.C. Nicolaou, C.F, Gelin, T. Lister, R.M. Denton, Abstracts, 41st Western Regional ACS meeting, San Diego, October 9-13, 2007